An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.
Olivia K L HamiltonQian ZhangAllan F McRaeRosie M WalkerStewart W MorrisPaul RedmondArchie I CampbellAlison D MurrayDavid J PorteousKathryn L EvansAndrew M McIntoshIan J DearyRiccardo E MarioniPublished in: International journal of obesity (2005) (2019)
We observed and replicated associations between an epigenetic score for BMI and variables related to poor physical health and metabolic syndrome. Regression models with both epigenetic and phenotypic BMI scores as predictors accounted for a greater proportion of variance in all outcome variables than either predictor alone, demonstrating independent and additive effects of epigenetic and phenotypic BMI scores.