The PIDDosome: centrosome guardian and backup on the DNA damage response.

Published in: Molecular & cellular oncology (2021)

The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.

Keyphrases

dna damage response
cell fate
protein protein
amino acid
cell death
signaling pathway
binding protein
high throughput
stress induced
single cell
label free