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Melastoma dodecandrum lour. Protects against cerebral ischemia-reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress.
Shuang Liu
Xiaoqin Zhang
Bingfeng Lin
Jiale Mao
Jianhu Zhan
Yanyan Li
Jiwang Zhou
Nani Wang
Weiwen Qiu
Published in:
Journal of ethnopharmacology (2024)
This study confirmed that the therapeutic mechanism of the MD extract on CIR injury was via the inhibition of oxidative stress and the ER stress pathway, in addition to the inhibition of apoptosis.
Keyphrases
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endoplasmic reticulum stress
oxidative stress
induced apoptosis
diabetic rats
dna damage
ischemia reperfusion injury
molecular dynamics
subarachnoid hemorrhage
brain injury
heat shock
anti inflammatory
cerebral ischemia
blood brain barrier