Inhibition of CREB-mediated ZO-1 and activation of NF-κB-induced IL-6 by colonic epithelial MCT4 destroys intestinal barrier function.
Shunxian ZhangWanfu XuHongli WangMeiwan CaoMusheng LiJunhong ZhaoYan HuYaodong WangSongyu LiYuanwen XieGuanhua ChenRuitao LiuYang ChengZhaohui XuKejian ZouSitang GongLanlan GengPublished in: Cell proliferation (2019)
These findings suggested a novel role of MCT4 in controlling development of IBD and provided evidence for potential targets of IBD.