CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes.
Valeria LeuciChiara DoniniGiovanni GrignaniRamona RotoloGiulia MesianoErika FiorinoLoretta GammaitoniLorenzo D'AmbrosioAlessandra MerliniElisa LandoniEnzo MedicoSonia CapelleroLidia GiraudoGiulia CattaneoIlenia IaiaYmera PignochinoMarco BasiricòElisa VignaAlberto PisacaneFranca FagioliSoldano FerroneMassimo AgliettaGianpietro DottiDario SangioloPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This study has shown that CSPG4-CAR.CIK effectively targets multiple STS histotypes in vitro and in immunodeficient mice. These results provide a strong rationale to translate the novel strategy we have developed into a clinical setting.