Temporary blood-brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma.

Antonin DréanNolwenn LemaireGuillaume BouchouxLauriane GoldwirtMichael CanneyLarissa GoliAmira BouzidiCharlotte SchmittJeremy GuehennecMaïté VerreaultMarc SansonJean-Yves DelattreKarima MokhtariFrédéric SottiliniAlexandre CarpentierAhmed Idbaïh

Published in: Journal of neuro-oncology (2019)

Carboplatin efficacy was enhanced in GBM mouse models with US-BBB and appears to be a promising chemotherapy for this approach.

Keyphrases

blood brain barrier
cerebral ischemia
phase ii study
mouse model
locally advanced
stem cells
squamous cell carcinoma
clinical trial
computed tomography
mesenchymal stem cells
brain injury
bone marrow
subarachnoid hemorrhage
chemotherapy induced