Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial.
Yasaman GhorbaniKatherine J P SchwengerDivya SharmaHyejung JungJitender YadavWei XuWendy LouSusan PoutanenSusy S HotaElena M ComelliDana PhilpottTimothy D JacksonAllan OkrainecHerbert Y GaisanoJohane P AllardPublished in: Diabetes, obesity & metabolism (2022)
Overall, in those with obeisty, allogenic FMT via colonoscopy induced favourable changes in IM, metabolites, pathway representations and networks even though other metabolic variables did not change. LDL and appetite variables may also benefit.
Keyphrases
- placebo controlled
- insulin resistance
- double blind
- weight loss
- metabolic syndrome
- high fat diet induced
- adipose tissue
- type diabetes
- clinical trial
- high fat diet
- phase ii
- phase iii
- skeletal muscle
- colorectal cancer screening
- study protocol
- drug induced
- high glucose
- polycystic ovary syndrome
- diabetic rats
- ms ms
- working memory
- microbial community
- phase ii study
- early onset
- body weight
- squamous cell carcinoma
- weight gain
- radiation therapy
- oxidative stress
- open label
- rectal cancer