Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis.

Annika WinboEva-Lena StattinIda Maria WestinAnna NorbergJohan PerssonSteen M JensenAnnika Rydberg

Published in: BMC medical genetics (2017)

Sex was identified as a moderator of the association between NOS1AP sequence variants and QTc in two LQT1 founder populations. This finding may contribute to QTc sex differences and affect the usefulness of NOS1AP as a marker for clinical risk stratification in LQTS.

Keyphrases

nitric oxide synthase
transcription factor
copy number
nitric oxide
amino acid
gene expression
drug induced
data analysis