The first reported case of Noonan syndrome complicated with hepatocellular carcinoma.

Satoru KakizakiDaisuke UeharaHiroki TojimaTakayoshi SugaYuichi YamazakiKen SatoNorio KuboKen ShirabeTakayuki YokotaKei ShibuyaTatsurou MaeharaHideaki YokooAtsushi NaganumaToshio Uraoka

Published in: Clinical case reports (2021)

Noonan syndrome is a genetic multisystem disorder and is associated with mutation of genes encoding the proteins in the RAS-MAPK pathway. We reported the first case of Noonan syndrome complicated with hepatocellular carcinoma.

Keyphrases

case report
genome wide
oxidative stress
transcription factor
bioinformatics analysis