Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure.

Kim de JongJ M VonkM ImbodenL LahousseA HofmanG G BrusselleN M Probst-HenschD S PostmaH M Boezen

Published in: Respiratory research (2017)

This unique, first genome-wide gene-by-ETS interaction study on the level of FEV1 showed that pathways previously implicated in chronic obstructive pulmonary disease (COPD), a disease characterized by airflow obstruction, may also underlie susceptibility to impaired lung function in the context of ETS exposure.

Keyphrases

lung function
genome wide
chronic obstructive pulmonary disease
cystic fibrosis
air pollution
transcription factor
dna methylation
copy number
genome wide identification
risk assessment
human health