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Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure.

Joann Romano-KeelerMeghan H ShiltsAndrey TovchigrechkoChunlin WangRobert M BruckerDaniel J MooreChristopher FonnesbeckShufang MengHernan CorreaHarold N LovvornYi-Wei TangLora HooperSeth R BordensteinSuman R DasJoern-Hendrik Weitkamp
Published in: PloS one (2018)
The observed low diversity in NEC tissues suggests that NEC is associated with a bacterial bloom and a distinct mucosal bacterial community. The exact bacterial species that constitute the bloom varied by infant and were strongly influenced by age and exposure to vancomycin.
Keyphrases
  • ulcerative colitis
  • gene expression
  • methicillin resistant staphylococcus aureus
  • low birth weight
  • preterm infants
  • genetic diversity