Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure.
Joann Romano-KeelerMeghan H ShiltsAndrey TovchigrechkoChunlin WangRobert M BruckerDaniel J MooreChristopher FonnesbeckShufang MengHernan CorreaHarold N LovvornYi-Wei TangLora HooperSeth R BordensteinSuman R DasJoern-Hendrik WeitkampPublished in: PloS one (2018)
The observed low diversity in NEC tissues suggests that NEC is associated with a bacterial bloom and a distinct mucosal bacterial community. The exact bacterial species that constitute the bloom varied by infant and were strongly influenced by age and exposure to vancomycin.