Tumor-targeted near-infrared fluorophore for fluorescence-guided phototherapy.

Min-Ho ParkGayoung JoEun Jeong KimJin Seok JungHoon Hyun

Published in: Chemical communications (Cambridge, England) (2020)

A tumor-targeted near-infrared (NIR) fluorophore CA800SO3 was developed for fluorescence-guided phototherapy. This new type of NIR fluorophore showed high tumor targetability based on the structure-inherent targeting approach. This fluorophore generated sufficient hyperthermia and reactive oxygen species (ROS) simultaneously for synergistic cancer phototherapy, induced by an 808 nm laser irradiation.

Keyphrases

fluorescent probe
reactive oxygen species
cancer therapy
photodynamic therapy
single molecule
cell death
fluorescence imaging
papillary thyroid
radiation therapy
high resolution
young adults