The mutational frequency of BRAF and KRAS in low-grade serous testicular neoplasms-a case series.

Paidamwoyo GwitiIldikó VereczkeyDavid CundellShazia AslamTim ClenchErzsébet CsernákKatalin GötzerJeremy BraybrookeMuhammed SohailZsombor Melegh

Published in: Histopathology (2017)

The findings of this study are in support of a role of aberrant signalling of the MAPK pathway in the pathogenesis of low-grade serous testicular neoplasms, and provide a genetic link between low-grade testicular and ovarian serous tumours.

Keyphrases

low grade
high grade
germ cell
signaling pathway
wild type
oxidative stress
genome wide
gene expression
copy number
dna methylation