Quantitative multiplex profiling of the complement system to diagnose complement-mediated diseases.
Esther WillemsLaura Lorés-MottaAndrea ZanichelliChiara SuffrittiMichiel van der FlierRenate G van der MolenJeroen D LangereisJoris van DrongelenLambert P van den HeuvelElena VolokhinaNicole Caj van de KarJenneke Keizer-GarritsenMichael LevinJethro A HerbergFederico Martinon-TorresHans Jtc WesselsAnita de BreukSascha FauserCarel B HoyngAnneke I den HollanderRonald de GrootAlain J van GoolJolein GloerichMarien I de JongePublished in: Clinical & translational immunology (2020)
Our study shows the potential clinical utility of profiling circulating complement proteins as a comprehensive read-out of various complement deficiencies. Particularly, our approach provides insight into the intricate interplay between complement proteins due to functional coupling, which contributes to the better understanding of the various disease phenotypes and improvement of care for patients with complement-mediated diseases.