Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.

Joseph O'Neill Mary J O'ConnorVictor YeeRonald LyKatherine NarrJeffrey R AlgerJennifer G Levitt

Published in: Birth defects research (2019)

These findings point to tract focal, white-matter pathology possibly specific for ADHD+PAE subjects. Low Cho may derive from abnormal choline metabolism; low FA suggests suboptimal white-matter integrity in PAE. More advanced MRSI and DTI-and neurocognitive assessments-may better distinguish ADHD+PAE from ADHD-PAE, helping identify covert cases of FASD.

Keyphrases

white matter
attention deficit hyperactivity disorder
working memory
autism spectrum disorder
multiple sclerosis
pregnant women
functional connectivity