Unsolved severe chronic rhinosinusitis elucidated by extensive CFTR genotyping.

Fanny DegrugillierStéphanie SimonAbdel AissatNatascha RemusChadia MekkiXavier DecrouyAurélie HattonAlexandre HinzpeterBrice HoffmannIsabelle Sermet-GaudelusIsabelle CallebautPascale FanenVirginie Prulière-Escabasse

Published in: Clinical case reports (2019)

Severe chronic rhinosinusitis in children should alert clinicians and extensive CFTR genotyping should be performed. We propose that thorough clinical and functional assessment in severe chronic rhinosinusitis is valuable to discover rare mutations which could be treated by CFTR correctors to postpone pulmonary infection.

Keyphrases

chronic rhinosinusitis
cystic fibrosis
early onset
high throughput
pulmonary hypertension
young adults
palliative care
gene expression
high density