The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing.
Leire Ruiz-CerdáEduardo Asin-PrietoZinnia P Parra-GuillenIñaki F TrocónizPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Pharmacokinetic modeling, traditionally using drug exposure, is widely used to support decision-making in translational medicine and patient care. The development of mechanistic computational models that integrate drug concentrations at the site of action making use of existing knowledge opens a new paradigm in optimal dosing. Clin Cancer Res; 24(14); 3236-8. ©2018 AACRSee related article by Ribba et al., p. 3325.