Dityrosine Aggravates Hepatic Insulin Resistance in Obese Mice by Altering Gut Microbiota and the LPS/TLR4/NF-κB Inflammatory Pathway.
Yin-Yi DingJinchi LanYumeng FangYuxiang PanZhenyu GuJing XueYing YangMengqi JiangYujun GeQing ShenPublished in: Molecular nutrition & food research (2023)
The effects of dityrosine on insulin resistance may be attributed to the reshaping of the gut microbiota composition and promoting the activity of the LPS/TLR4/NF-κB inflammatory pathway in HFD-induced obese individuals.
Keyphrases
- inflammatory response
- lps induced
- oxidative stress
- toll like receptor
- nuclear factor
- insulin resistance
- signaling pathway
- adipose tissue
- high fat diet
- diabetic rats
- metabolic syndrome
- type diabetes
- immune response
- anti inflammatory
- weight loss
- polycystic ovary syndrome
- skeletal muscle
- bariatric surgery
- cell proliferation
- high fat diet induced
- endothelial cells