1,6-Hexanediol regulates angiogenesis via suppression of cyclin A1-mediated endothelial function.

Yongying JiangGongyun LeiTing LinNan ZhouJintao WuZhou WangYihui FanHongzhuan ShengRenfang Mao

Published in: BMC biology (2023)

Our data reveal a critical role of LLPS inhibitor 1,6-HD in angiogenesis and endothelial function, which specifically affects endothelial G1/S transition through transcriptional suppression of CCNA1, implying LLPS as a possible novel player to modulate angiogenesis, and thus, it might represent an interesting therapeutic target to be investigated in clinic angiogenesis-related diseases in future.

Keyphrases

endothelial cells
vascular endothelial growth factor
wound healing
primary care
current status
transcription factor
electronic health record
big data
single cell
high resolution
dna methylation
mass spectrometry
genome wide
cell death
cell cycle arrest
deep learning
single molecule
cell proliferation