Developing a novel magnetic organic polymer for selective extraction and determination of 16 macrolides in water and honey samples.
Mengnan LiangNa LiHao ZhangLing MaKe WangPublished in: RSC advances (2024)
A novel magnetic organic polymer Fe 3 O 4 @SiO 2 @Tb-PDAN was designed and synthesized, which was used as an adsorbent for magnetic solid-phase extraction (MSPE) of 16 macrolides (MALs) in water and honey. The synthesized adsorbent was characterized using techniques including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Then several parameters of the extraction process were further optimized. Under the optimized conditions, an MSPE-LC-MS/MS method was established for extraction and determination of 16 MALs, which showed good linearity ( r ≥ 0.999), low limits of detection (0.001-0.012 μg L -1 for water and 0.001-0.367 μg kg -1 for honey) and satisfactory recoveries (70.02-118.91%) with the relative standard deviations (RSDs) lower than 10.0%. This established method was then successfully applied to detect MALs in real samples, which suggested that Fe 3 O 4 @SiO 2 @Tb-PDAN was a potential magnetic adsorbent for efficient extraction and analysis of MALs.
Keyphrases
- solid phase extraction
- molecularly imprinted
- electron microscopy
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- simultaneous determination
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- gas chromatography
- mycobacterium tuberculosis
- high resolution
- mass spectrometry
- risk assessment
- high resolution mass spectrometry
- magnetic nanoparticles
- label free
- dual energy
- ms ms