Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

Soo Ki KimHaruhiko TakedaAtsushi TakaiTomonori MatsumotoNobuyuki KakiuchiAkira YokoyamaKenichi YoshidaToshimi KaidoShinji UemotoSachiko MinamiguchiHironori HagaYuichi ShiraishiSatoru MiyanoHiroshi SenoSeishi OgawaHiroyuki Marusawa

Published in: Journal of gastroenterology (2019)

Analyses of RNs constructing cirrhotic liver indicated that a variety of genetic aberrations accumulate in the cirrhotic liver before the development of clinically and histologically overt HCC. These aberrations in RNs could provide the basis of tumorigenesis in patients with liver cirrhosis.

Keyphrases

copy number
genome wide
stem cells
mesenchymal stem cells
dna methylation
cell therapy
gene expression
tissue engineering