Angiogenic Factor and Cytokine Analysis among Patients Treated with Adjuvant VEGFR TKIs in Resected Renal Cell Carcinoma.
Wenxin XuManeka PuligandlaJudith ManolaAndrea J BullockDaniel TamasauskasDavid F McDermottMichael B AtkinsNaomi B HaasKeith FlahertyRobert G UzzoJanice P DutcherRobert S DiPaolaRupal S BhattPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Among patients treated with adjuvant VEGFR TKIs for RCC, drug-host interactions mediate changes in circulating cytokines. Elevated baseline CXCL10 was associated with worse DFS. Studies to understand functional consequences of these changes are under way.