Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation.

Jihyun LimSorim NamJi Hye JeongMin Jung KimYoung YangMyeong-Sok LeeHee Gu LeeJae-Ha RyuJong-Seok Lim

Published in: British journal of pharmacology (2019)

Our findings suggest that kazinol U reduces melanogenesis via its inhibitory effect on MITF and its downstream target genes, tyrosinase, Tyrp1 and Tyrp2. This work may provide a basis for the application of kazinol U for the treatment of hyperpigmentation skin disorders.

Keyphrases

protein kinase
genome wide
soft tissue
tyrosine kinase
dna methylation
wound healing
combination therapy
genome wide identification
bioinformatics analysis
smoking cessation