Exploring the impact of ethnicity on drug pharmacokinetics using PBPK models: a case study with lansoprazole in Japanese subjects.

Udoamaka Ezuruike Liam CurryOliver HatleyIain Gardner

Published in: British journal of clinical pharmacology (2023)

By accounting for various physiological parameters that characterise a population in a PBPK model, the impact of the different identified inter-ethnic differences on the drug's PK can be explored, which can inform the adoption of drugs from one region to another.

Keyphrases

drug induced
adverse drug
emergency department