Modern simulation utilities for genetic analysis.
Sarah S JiChristopher A GermanKenneth LangeJanet S SinsheimerHua ZhouJin ZhouEric M SobelPublished in: BMC bioinformatics (2021)
The TraitSimulation package has three main advantages. (1) It leverages the computational efficiency and ease of use of Julia to provide extremely fast, straightforward simulation of even the most complex genetic models, including GLMs and GLMMs. (2) It can be operated entirely within, but is not limited to, the integrated analysis pipeline of OpenMendel. And finally (3), by allowing a wider range of more realistic phenotype models, TraitSimulation brings power calculations and diagnostic tools closer to what investigators might see in real-world analyses.