Asthma development is associated with low mucosal IL-10 during viral infections in early life.
Mathias Elsner MelgaardSigne Kjeldgaard JensenAnders EliasenCasper-Emil Tingskov PedersenJonathan ThorsenMarianne MikkelsenNilofar VahmanAnn-Marie Malby SchoosJames E GernSusanne BrixJessica Lasky-SuBo Lund ChawesKlaus BønnelykkePublished in: Allergy (2024)
We described the airway immune mediator profile during viral respiratory illnesses in early life and showed that children developing asthma by age 6 years have a reduced regulatory (IL-10) immune mediator level. This provides insight into the interplay between early-life viral infections, airway immunity and asthma development.