Phosphodiesterase type 5 inhibitor attenuates chronic ischemia-induced prostatic hyperplasia in a rat model.

Shinji FujiiShinichi YamashitaNatsuho HayashiTakuro GotoJuntaro KoyamaTakuma SatoShuichi ShimadaYoshihide KawasakiHideaki IzumiNaoki KawamoritaKoji MitsuzukaAkihiro ItoYoichi Arai

Published in: The Prostate (2018)

Enlargement of the VP resulted from chronic ischemia induced by local arteriosclerosis. Also, administration of tadalafil attenuated VP enlargement. Chronic ischemia in the prostate might thus contribute to the development of BPH, and PDE5 inhibitors might provide an innovative approach to preventing BPH.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
prostate cancer
drug induced