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Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study.

Darryl P LeongAli ZhangJessica A BreznikRumi ClareAngela HuynhMaha MushtahaSumathy RangarajanHannah StaceyPaul Y KimMark LoebJudah A DenburgDominik MertzZain ChaglaIshac NazyMatthew S MillerDawn M E BowdishMyLinh Duong
Published in: PloS one (2023)
This is the first comprehensive study to compare 3 dosing intervals for the primary vaccination of BNT162b2 mRNA COVID-19 vaccine implemented in the real world. These findings suggest that delaying the second dose beyond 42 days can potentiate and prolong the humoral response against ancestral and Beta variants of SARS-CoV-2 up to 9 months post-vaccination.
Keyphrases
  • sars cov
  • immune response
  • respiratory syndrome coronavirus
  • dendritic cells
  • coronavirus disease
  • binding protein
  • toll like receptor