Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats.
Haiyan ChiYujing SunPeng LinJunyu ZhouJinbiao ZhangYachao YangYun QiaoDeshan LiuPublished in: Journal of diabetes research (2024)
GF aggravates cognitive impairment by inhibiting the Nrf2 signaling pathway and inducing oxidative stress and apoptosis in the hippocampal tissues.
Keyphrases
- diabetic rats
- oxidative stress
- cognitive impairment
- signaling pathway
- induced apoptosis
- pi k akt
- gene expression
- dna damage
- ischemia reperfusion injury
- epithelial mesenchymal transition
- cerebral ischemia
- cell cycle arrest
- temporal lobe epilepsy
- blood glucose
- heat shock
- cell proliferation
- brain injury
- cell death
- subarachnoid hemorrhage
- blood brain barrier