Four iridium (III) complexes Ir1-Ir4 were synthesized and characterized. Possessing high singlet oxygen production ability and specific mitochondria-localization, Ir1 was developed as a mitochondria-targeting photosensitizer. Ir1 exhibited strong phototoxicity against cancer cell line A549 and its corresponding cisplatin-resistant one A549R. In contrast, Ir1 showed low cytotoxicity toward normal cell HLF. This selectivity resulted from the different uptake amount. With 405 nm irradiation, Ir1 induced mitochondria-mediated cell death in A549R cells, achieving the overcome of drug-resistant.
Keyphrases
- cell death
- cell cycle arrest
- drug resistant
- photodynamic therapy
- induced apoptosis
- multidrug resistant
- reactive oxygen species
- endoplasmic reticulum
- magnetic resonance
- acinetobacter baumannii
- cancer therapy
- papillary thyroid
- radiation therapy
- magnetic resonance imaging
- stem cells
- squamous cell carcinoma
- signaling pathway
- oxidative stress
- computed tomography
- drug delivery
- mesenchymal stem cells
- lymph node metastasis
- oxide nanoparticles