SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells.
Ana Sofia RibeiroAna Rita NobreNuno MendesJoão AlmeidaAndré Filipe VieiraBárbara SousaFilomena A CarvalhoJoana MonteiroAntónio PolóniaMartina FonsecaJoão Miguel SanchesNuno C SantosRaquel SerucaJoana ParedesPublished in: Cell communication and signaling : CCS (2018)
In conclusion our findings show that targeting P-cadherin/SRC signaling and functional activity may open novel therapeutic opportunities for highly aggressive and poor prognostic basal-like breast cancer.