Dual orexin antagonist DORA-22 normalized sleep homeostatic drive, enhanced GABAergic inhibition and suppressed seizures after traumatic brain injury.
Sruthi R KonduruJesse R IsaacsonDanny J LaskyZihao ZhouRohan K RaoSwati S VattemSophie J ReweyMathew V JonesRama K MagantiPublished in: Sleep (2022)
Dual orexin antagonists may have a therapeutic potential in suppressing PTE potentially by enhancing GABAergic inhibition and impacting sleep homeostatic drive.
Keyphrases