Regional microglial activation in the substantia nigra is linked with fatigue in MS.

Tarun SinghalSteven CiceroHong PanKelsey CarterShipra DubeyRenxin ChuBonnie GlanzShelley HurwitzShahamat TauhidMi-Ae ParkMarie KijewskiEmily SternRohit BakshiDavid SilbersweigHoward L Weiner

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

Substantia nigra microglial activation is linked to fatigue in MS. Microglial activation across key brain regions may represent a unifying mechanism for MSAF, and further evaluation of neuroimmunologic basis of MSAF is warranted.

Keyphrases

inflammatory response
lipopolysaccharide induced
mass spectrometry
lps induced
multiple sclerosis
neuropathic pain
ms ms
sleep quality
white matter
resting state
spinal cord
brain injury