SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
Oliver Daniel SchwichNicole BlümelMario KellerMarius WegenerSamarth Thonta SettyMelinda Elaine BrunsteinIna PoserIgor Ruiz De Los MozosBeatrix SuessChristian MünchFrançois McNicollKathi ZarnackMichaela Müller-McNicollPublished in: Genome biology (2021)
We demonstrate that SRSF3 and SRSF7 are direct modulators of pPAS usage and show how small differences in the domain architecture of SR proteins can confer opposite effects on pPAS regulation.
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