The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling.
Dustin T MaydaniukBrielle MartensSarah IqbalAndrew M HoganNeil Lorente CoboAnna MotnenkoDang TruongSajani H LiyanageMingdi YanGerd PrehnaSilvia T CardonaPublished in: Microbiology spectrum (2024)
The Burkholderia cepacia complex is a group of multidrug-resistant bacteria that can cause infections in the lungs of people with the autosomal recessive disease, cystic fibrosis. Specifically, the bacterium Burkholderia cenocepacia can cause severe infections, reducing lung function and leading to a devastating type of sepsis, cepacia syndrome. This bacterium currently does not have an accepted antibiotic treatment plan because of the wide range of antibiotic resistance. Here, we further the research on auranofin analogs as antimicrobials by finding the mechanism of action of these potent bactericidal compounds, using a powerful technique called BarSeq, to find the global response of the cell when exposed to an antimicrobial.
Keyphrases
- lung function
- cystic fibrosis
- multidrug resistant
- single cell
- chronic obstructive pulmonary disease
- air pollution
- pseudomonas aeruginosa
- molecular docking
- intensive care unit
- staphylococcus aureus
- cell therapy
- drug resistant
- gram negative
- early onset
- intellectual disability
- anti inflammatory
- escherichia coli
- replacement therapy
- bone marrow
- molecular dynamics simulations