Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

Mirela Georgiana Perne Adela-Viviana Sitar-Tăut Teodora Gabriela AlexescuLorena CiumărneanMircea-Vasile MilaciuSorina-Cezara CosteCalin-Vasile VladAngela CozmaDan-Andrei Sitar-TăutOlga Hilda OrăşanAlexandra Marioara Craciun

Published in: Diagnostics (Basel, Switzerland) (2023)

a total number of 37 studies (5037 patients with HCC vs. 8199 patients-control group) have been included in the meta-analysis. PIVKA II presented a better diagnostic accuracy in HCC diagnostic vs. alpha-fetoprotein (global PIVKA II AUROC 0.851 vs. AFP AUROC 0.808, respectively, 0.790 vs. 0.740 in early HCC cases). The conclusion from a clinical point of view, concomitant use of PIVKA II and AFP can bring useful information, added to that brought by ultrasound examination.

Keyphrases

systematic review
end stage renal disease
newly diagnosed
ejection fraction
magnetic resonance imaging
chronic kidney disease
case control
prognostic factors
peritoneal dialysis
healthcare
small molecule
patient reported outcomes
computed tomography
binding protein
protein protein
health information