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p -Methoxybenzyl-Radical-Promoted Chemoselective Protection of sec -Alkylamides.

JingWen JiaTerumasa KatoKeiji Maruoka
Published in: The Journal of organic chemistry (2023)
The hitherto difficult site-selective p -methoxybenzylation of secondary amides using p -methoxybenzylated alkylsilyl peroxides as a novel p -methoxybenzylation agent under copper catalysis is reported. The reaction proceeds under mild reaction conditions in a highly chemoselective manner. This approach was successfully applied to the site-selective p -methoxybenzylation of peptides.
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