The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in Rats.
Rosalba SiracusaRoberta FuscoMarika CordaroAlessio Filippo PeritoreRamona D'amicoEnrico GugliandoloRosalia CrupiTiziana GenoveseMaurizio EvangelistaRosanna Di PaolaSalvatore CuzzocreaDaniela ImpellizzeriPublished in: International journal of molecular sciences (2020)
The results obtained reinforce the idea that PEA-m may be a potential treatment for the control of pain and inflammatory processes associated with PO. In addition, pre- and post-treatment with PEA-m is more effective than treatment alone after the surgery and this limits the time of taking the compound and the abuse of analgesics.