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Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.

Jing-Jing FanWei-Dong DingYing-Fan LiangYao-Xin WeiYi HuangLei MaRui Wang
Published in: American journal of translational research (2024)
-induced mitochondrial dysfunction and neuronal injury via promoting AMPK/PGC-1α signaling activation and be used as a therapeutic drug for PD treatment.
Keyphrases
  • skeletal muscle
  • high glucose
  • diabetic rats
  • drug induced
  • oxidative stress
  • endothelial cells
  • combination therapy
  • brain injury
  • water soluble