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Functional biomaterials for osteoarthritis treatment: From research to application.

Yang LeiQingfei ZhangGaizheng KuangXiaochen WangQihui FanFangfu Ye
Published in: Smart medicine (2022)
Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.
Keyphrases
  • knee osteoarthritis
  • drug release
  • rheumatoid arthritis
  • drug delivery
  • stem cells
  • combination therapy
  • quality improvement
  • mesenchymal stem cells
  • current status
  • extracellular matrix