Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice.

L GanZ LiuF FengT WuD LuoC HuChao Sun

Published in: International journal of obesity (2005) (2017)

Our results indicated that Foxc2 inhibited inflammation and promoted browning of WAT through positive regulation of leptin signal and the STAT3-PRDM16 complex. These findings identify a new potential means to prevent and treat obese caused metabolic syndrome of mammals.

Keyphrases

metabolic syndrome
high fat diet induced
insulin resistance
oxidative stress
adipose tissue
cell proliferation
type diabetes
uric acid