Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats.

Nahla N YounisNehal M ElsherbinyMohamed A Shaheen Mohamed M Elseweidy

Published in: The Journal of pharmacy and pharmacology (2020)

The antioxidant mechanism by which vanillin protected against CP-induced nephrotoxicity involved the inhibition of NOX-4 along with the stimulation of Nrf2/HO-1 signalling pathway. These in turn inhibited inflammation and apoptosis.

Keyphrases

oxidative stress
diabetic rats
drug induced
pi k akt
high glucose
fluorescent probe
sensitive detection
signaling pathway
reactive oxygen species
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
cell death