Disparities in bone density across contemporary Amazonian forager-horticulturalists: Cross-population comparison of the Tsimane and Shuar.
Felicia C MadimenosMelissa A LiebertTara J Cepon-RobinsSamuel S UrlacherJ Josh SnodgrassLawrence S SugiyamaJonathan StieglitzPublished in: American journal of physical anthropology (2019)
Disparate patterns in QUS values are documented for Tsimane and Shuar, with pronounced differences early in life. Potential explanations for differences include gene-environment interactions and/or degree of market integration, which influences diet, activity profiles, pathogen exposures, and other lifestyle covariates. As Tsimane osteoporosis risk is greater than in the United States, findings point to alternative risk factors for low bone density that are not readily discernible in industrialized populations.
Keyphrases
- bone mineral density
- postmenopausal women
- physical activity
- weight loss
- soft tissue
- bone loss
- body composition
- metabolic syndrome
- air pollution
- bone regeneration
- cardiovascular disease
- copy number
- genome wide
- health insurance
- gene expression
- risk assessment
- healthcare
- climate change
- genetic diversity
- clinical evaluation
- breast cancer risk