COVID-19 induces neuroinflammation and suppresses peroxisomes in the brain.
A RoczkowskyD LimontaJ P FernandesW G BrantonM ClarkeB HlavayR S NoyceJ T JosephN S OgandoS K DasM ElaishN ArbourD H EvansK LangdonT C HobmanChristopher PowerPublished in: Annals of neurology (2023)
COVID-19 induced sustained neuroinflammatory responses with peroxisome biogenesis factor suppression despite limited brainstem SARS-CoV-2 neurotropism in humans. These observations offer insights into developing biomarkers and therapies, while also implicating persistent peroxisome dysfunction as a contributor to the neurological post-acute sequelae of COVID-19. This article is protected by copyright. All rights reserved.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- drug induced
- oxidative stress
- liver failure
- traumatic brain injury
- high glucose
- cerebral ischemia
- white matter
- diabetic rats
- signaling pathway
- intensive care unit
- lps induced
- respiratory failure
- resting state
- inflammatory response
- multiple sclerosis
- endothelial cells
- mechanical ventilation