The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids.
Jelena MedvedBrittney M KnottSoraya N TarrahAndria N LiNeha ShahTamara C MoscovichAlexis R BosciaJuan E SalazarManjula SanthanakrishnanJeanne Elise HendricksonXiaoyun FuJames C ZimringChance John LuckeyPublished in: Transfusion (2021)
Although storage of RBCs leads to alteration of several lysophospholipids known to be capable of binding CD1D, storage-induced RBC alloimmunization responses are not impacted by recipient CD1D deficiency.