Persistent COVID-19: a case report of an immunocompromised patient and a literature review.
Sirine BekkaouiGeoffroy VentonFannie BretelleVictoria GarridoVictor ChabbertStéphane GayetPaul DalmasAntoine TichadouPierre-André JarrotPatrick VillaniAurélie DaumasRobin ArcaniPublished in: Acta haematologica (2024)
Introduction Immunocompromised patients can show prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and persistent symptoms, which is called persistent COVID-19. Case presentation We report a case of an immunocompromised patient who was treated for mantle cell lymphoma and was suffering from B-cell depletion. The patient developed persistent COVID-19, which was confirmed by real-time polymerase chain reaction (RT-PCR) tests in only sputum and bronchoalveolar fluid which remained positive for at least 112 days. The patient was successfully treated with SARS-CoV-2 convalescent plasma. Conclusion It could be of interest to investigate the RT-PCR results of SARS-CoV-2 in sputum/bronchoalveolar lavage samples from immunocompromised patients with unexplained pneumonia.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- case report
- coronavirus disease
- cystic fibrosis
- mycobacterium tuberculosis
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- physical activity
- prognostic factors
- pulmonary tuberculosis
- intensive care unit
- acute respiratory distress syndrome
- depressive symptoms
- patient reported outcomes
- sleep quality