Zoonotic vaccinia virus strains belonging to different genetic clades exhibit immunomodulation abilities that are proportional to their virulence.

Karine Lima LourençoLeandro Andrade ChináliaLethícia Ribeiro HenriquesRodrigo Araújo Lima RodriguesFlavio Guimarães da Fonseca

Published in: Virology journal (2021)

Our results suggest that VACV immunomodulation in vivo is clade-related and is proportional to the strain's virulence upon infection. Our data corroborate the classification of the different Brazilian VACV isolates into clades 1 and 2, taking into account not only phylogenetic criteria, but also clinical and immunological data.

Keyphrases

escherichia coli
pseudomonas aeruginosa
staphylococcus aureus
electronic health record
antimicrobial resistance
biofilm formation
big data
machine learning
deep learning
cystic fibrosis
gene expression
data analysis
dna methylation
genetic diversity
candida albicans