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Expansion of chronic lesions is linked to disease progression in relapsing-remitting multiple sclerosis patients.

Samuel KlistornerMichael Harry BarnettCon YiannikasJoshua BartonJohn ParrattYuyi YouStuart L GrahamAlexander Klistorner
Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
Expansion of chronic lesions in RRMS patients is the primary determinant of increased T2 total lesion load. It significantly contributes to disease progression and partially driving axonal loss inside the lesions and brain damage outside of lesional tissue.
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