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Cardiac Metabolism in Sepsis.

Satoshi KawaguchiMotoi Okada
Published in: Metabolites (2021)
The mechanism of sepsis-induced cardiac dysfunction is believed to be different from that of myocardial ischemia. In sepsis, chemical mediators, such as endotoxins, cytokines, and nitric oxide, cause metabolic abnormalities, mitochondrial dysfunction, and downregulation of β-adrenergic receptors. These factors inhibit the production of ATP, essential for myocardial energy metabolism, resulting in cardiac dysfunction. This review focuses on the metabolic changes in sepsis, particularly in the heart. In addition to managing inflammation, interventions focusing on metabolism may be a new therapeutic strategy for cardiac dysfunction due to sepsis.
Keyphrases
  • left ventricular
  • septic shock
  • acute kidney injury
  • intensive care unit
  • oxidative stress
  • nitric oxide
  • heart failure
  • diabetic rats
  • atrial fibrillation
  • drug induced