Diabetic Kidney Disease versus Primary Glomerular Disease: A Propensity Score-Matched Analysis of Association between Ambulatory Blood-Pressure Monitoring and Target-Organ Damage.
Tiantian YuShicong SongXiaoqiu ChenTanqi LouJun ZhangHui PengMan LiCheng WangPublished in: Journal of clinical medicine (2022)
Diabetic kidney disease (DKD) and primary glomerular disease (PGD) are the main causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD). This study was conducted to compare the characteristics of ambulatory blood-pressure monitoring (ABPM) and its relationship with target-organ damage (TOD) in patients with DKD and PGD matched by propensity score. The assessment of TOD included macroalbuminuria, left ventricular hypertrophy (LVH) and macrovascular disease. Propensity-score weighting (PSW) was used in stratified analysis. Results: Patients with DKD had a higher prevalence of abnormal blood-pressure patterns such as reversed dipper pattern, nocturnal hypertension, and sustained hypertension and had a higher prevalence of TOD than did patients with PGD. Logistic regression indicated that patients with DKD were more related to TOD than to PGD. The stratified analysis indicated that DKD patients with white-coat hypertension, masked hypertension and sustained hypertension had closer relationships with TOD compared with PGD patients. Conclusion: Patients with type 2 diabetic kidney disease had more abnormal blood-pressure patterns and were more closely related to target organ damage than were patients with primary glomerular disease.
Keyphrases
- blood pressure
- end stage renal disease
- chronic kidney disease
- peritoneal dialysis
- hypertensive patients
- heart rate
- type diabetes
- left ventricular
- oxidative stress
- blood glucose
- newly diagnosed
- wound healing
- acute myocardial infarction
- diabetic nephropathy
- skeletal muscle
- high glucose
- coronary artery disease
- aortic valve
- atrial fibrillation
- sleep quality
- endothelial cells
- weight loss
- data analysis